Pesquisa | BVS Doenças Infecciosas e Parasitárias

1.

Malaria: Biology and Disease.

Cowman, Alan F; Healer, Julie; Marapana, Danushka; Marsh, Kevin.

Cell ; 167(3): 610-624, 2016 Oct 20.

Artigo em Inglês | MEDLINE | ID: mdl-27768886

2.

Structure of Plasmodium falciparum Rh5-CyRPA-Ripr invasion complex.

Wong, Wilson; Huang, Rick; Menant, Sebastien; Hong, Chuan; Sandow, Jarrod J; Birkinshaw, Richard W; Healer, Julie; Hodder, Anthony N; Kanjee, Usheer; Tonkin, Christopher J; Heckmann, Denise; Soroka, Vladislav; Søgaard, Teit Max Moscote; Jørgensen, Thomas; Duraisingh, Manoj T; Czabotar, Peter E; de Jongh, Willem A; Tham, Wai-Hong; Webb, Andrew I; Yu, Zhiheng; Cowman, Alan F.

Nature ; 565(7737): 118-121, 2019 01.

Artigo em Inglês | MEDLINE | ID: mdl-30542156

3.

Molecular profiling reveals features of clinical immunity and immunosuppression in asymptomatic P. falciparum malaria.

Studniberg, Stephanie I; Ioannidis, Lisa J; Utami, Retno A S; Trianty, Leily; Liao, Yang; Abeysekera, Waruni; Li-Wai-Suen, Connie S N; Pietrzak, Halina M; Healer, Julie; Puspitasari, Agatha M; Apriyanti, Dwi; Coutrier, Farah; Poespoprodjo, Jeanne R; Kenangalem, Enny; Andries, Benediktus; Prayoga, Pak; Sariyanti, Novita; Smyth, Gordon K; Cowman, Alan F; Price, Ric N; Noviyanti, Rintis; Shi, Wei; Garnham, Alexandra L; Hansen, Diana S.

Mol Syst Biol ; 18(4): e10824, 2022 04.

Artigo em Inglês | MEDLINE | ID: mdl-35475529

4.

Nanobodies against Pfs230 block Plasmodium falciparum transmission.

Dietrich, Melanie H; Gabriela, Mikha; Reaksudsan, Kitsanapong; Dixon, Matthew W A; Chan, Li-Jin; Adair, Amy; Trickey, Stephanie; O'Neill, Matthew T; Tan, Li Lynn; Lopaticki, Sash; Healer, Julie; Keremane, Sravya; Cowman, Alan F; Tham, Wai-Hong.

Biochem J ; 479(24): 2529-2546, 2022 12 22.

Artigo em Inglês | MEDLINE | ID: mdl-36520108

5.

Naturally acquired antibody kinetics against Plasmodium vivax antigens in people from a low malaria transmission region in western Thailand.

Liu, Zoe Shih-Jung; Sattabongkot, Jetsumon; White, Michael; Chotirat, Sadudee; Kumpitak, Chalermpon; Takashima, Eizo; Harbers, Matthias; Tham, Wai-Hong; Healer, Julie; Chitnis, Chetan E; Tsuboi, Takafumi; Mueller, Ivo; Longley, Rhea J.

BMC Med ; 20(1): 89, 2022 03 09.

Artigo em Inglês | MEDLINE | ID: mdl-35260169

6.

Safety, infectivity and immunogenicity of a genetically attenuated blood-stage malaria vaccine.

Webster, Rebecca; Sekuloski, Silvana; Odedra, Anand; Woolley, Stephen; Jennings, Helen; Amante, Fiona; Trenholme, Katharine R; Healer, Julie; Cowman, Alan F; Eriksson, Emily M; Sathe, Priyanka; Penington, Jocelyn; Blanch, Adam J; Dixon, Matthew W A; Tilley, Leann; Duffy, Michael F; Craig, Alister; Storm, Janet; Chan, Jo-Anne; Evans, Krystal; Papenfuss, Anthony T; Schofield, Louis; Griffin, Paul; Barber, Bridget E; Andrew, Dean; Boyle, Michelle J; de Labastida Rivera, Fabian; Engwerda, Christian; McCarthy, James S.

BMC Med ; 19(1): 293, 2021 11 22.

Artigo em Inglês | MEDLINE | ID: mdl-34802442

7.

Neutralising antibodies block the function of Rh5/Ripr/CyRPA complex during invasion of Plasmodium falciparum into human erythrocytes.

Healer, Julie; Wong, Wilson; Thompson, Jennifer K; He, Wengqiang; Birkinshaw, Richard W; Miura, Kazutoyo; Long, Carol A; Soroka, Vladislav; Søgaard, Teit Max Moscote; Jørgensen, Thomas; de Jongh, Willem A; Weir, Christopher; Svahn, Ella; Czabotar, Peter E; Tham, Wai-Hong; Mueller, Ivo; Barlow, Paul N; Cowman, Alan F.

Cell Microbiol ; 21(7): e13030, 2019 07.

Artigo em Inglês | MEDLINE | ID: mdl-30965383

8.

A bioreactor system for the manufacture of a genetically modified Plasmodium falciparum blood stage malaria cell bank for use in a clinical trial.

Pawliw, Rebecca; Farrow, Rebecca; Sekuloski, Silvana; Jennings, Helen; Healer, Julie; Phuong, Thuan; Sathe, Pri; Pasay, Cielo; Evans, Krystal; Cowman, Alan F; Schofield, Louis; Chen, Nanhua; McCarthy, James; Trenholme, Katharine.

Malar J ; 17(1): 283, 2018 Aug 06.

Artigo em Inglês | MEDLINE | ID: mdl-30081913

9.

Mechanisms of naturally acquired immunity to P. falciparum and approaches to identify merozoite antigen targets.

Healer, Julie; Chiu, Chris Y; Hansen, Diana S.

Parasitology ; 145(7): 839-847, 2018 06.

Artigo em Inglês | MEDLINE | ID: mdl-29144217

10.

Different Regions of Plasmodium falciparum Erythrocyte-Binding Antigen 175 Induce Antibody Responses to Infection of Varied Efficacy.

Chiu, Chris Y; White, Michael T; Healer, Julie; Thompson, Jenny K; Siba, Peter M; Mueller, Ivo; Cowman, Alan F; Hansen, Diana S.

J Infect Dis ; 214(1): 96-104, 2016 07 01.

Artigo em Inglês | MEDLINE | ID: mdl-27020092

11.

Identification and prioritization of merozoite antigens as targets of protective human immunity to Plasmodium falciparum malaria for vaccine and biomarker development.

Richards, Jack S; Arumugam, Thangavelu U; Reiling, Linda; Healer, Julie; Hodder, Anthony N; Fowkes, Freya J I; Cross, Nadia; Langer, Christine; Takeo, Satoru; Uboldi, Alex D; Thompson, Jennifer K; Gilson, Paul R; Coppel, Ross L; Siba, Peter M; King, Christopher L; Torii, Motomi; Chitnis, Chetan E; Narum, David L; Mueller, Ivo; Crabb, Brendan S; Cowman, Alan F; Tsuboi, Takafumi; Beeson, James G.

J Immunol ; 191(2): 795-809, 2013 Jul 15.

Artigo em Inglês | MEDLINE | ID: mdl-23776179

12.

A next-generation genetically attenuated Plasmodium falciparum parasite created by triple gene deletion.

Mikolajczak, Sebastian A; Lakshmanan, Viswanathan; Fishbaugher, Matthew; Camargo, Nelly; Harupa, Anke; Kaushansky, Alexis; Douglass, Alyse N; Baldwin, Michael; Healer, Julie; O'Neill, Matthew; Phuong, Thuan; Cowman, Alan; Kappe, Stefan H I.

Mol Ther ; 22(9): 1707-15, 2014 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-24827907

13.

Kinetic flux profiling elucidates two independent acetyl-CoA biosynthetic pathways in Plasmodium falciparum.

Cobbold, Simon A; Vaughan, Ashley M; Lewis, Ian A; Painter, Heather J; Camargo, Nelly; Perlman, David H; Fishbaugher, Matthew; Healer, Julie; Cowman, Alan F; Kappe, Stefan H I; Llinás, Manuel.

J Biol Chem ; 288(51): 36338-50, 2013 Dec 20.

Artigo em Inglês | MEDLINE | ID: mdl-24163372

14.

Insights into Duffy binding-like domains through the crystal structure and function of the merozoite surface protein MSPDBL2 from Plasmodium falciparum.

Hodder, Anthony N; Czabotar, Peter E; Uboldi, Alessandro D; Clarke, Oliver B; Lin, Clara S; Healer, Julie; Smith, Brian J; Cowman, Alan F.

J Biol Chem ; 287(39): 32922-39, 2012 Sep 21.

Artigo em Inglês | MEDLINE | ID: mdl-22843685

15.

Modulation of PF10_0355 (MSPDBL2) alters Plasmodium falciparum response to antimalarial drugs.

Van Tyne, Daria; Uboldi, Alessandro D; Healer, Julie; Cowman, Alan F; Wirth, Dyann F.

Antimicrob Agents Chemother ; 57(7): 2937-41, 2013 Jul.

Artigo em Inglês | MEDLINE | ID: mdl-23587962

16.

A var gene promoter controls allelic exclusion of virulence genes in Plasmodium falciparum malaria.

Voss, Till S; Healer, Julie; Marty, Allison J; Duffy, Michael F; Thompson, Jennifer K; Beeson, James G; Reeder, John C; Crabb, Brendan S; Cowman, Alan F.

Nature ; 439(7079): 1004-8, 2006 Feb 23.

Artigo em Inglês | MEDLINE | ID: mdl-16382237

17.

Assessment of IgG3 as a serological exposure marker for Plasmodium vivax in areas with moderate-high malaria transmission intensity.

Tayipto, Yanie; Rosado, Jason; Gamboa, Dionicia; White, Michael T; Kiniboro, Benson; Healer, Julie; Opi, D Herbert; Beeson, James G; Takashima, Eizo; Tsuboi, Takafumi; Harbers, Matthias; Robinson, Leanne; Mueller, Ivo; Longley, Rhea J.

Front Cell Infect Microbiol ; 12: 950909, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-36017364

18.

PCRCR complex is essential for invasion of human erythrocytes by Plasmodium falciparum.

Scally, Stephen W; Triglia, Tony; Evelyn, Cindy; Seager, Benjamin A; Pasternak, Michal; Lim, Pailene S; Healer, Julie; Geoghegan, Niall D; Adair, Amy; Tham, Wai-Hong; Dagley, Laura F; Rogers, Kelly L; Cowman, Alan F.

Nat Microbiol ; 7(12): 2039-2053, 2022 12.

Artigo em Inglês | MEDLINE | ID: mdl-36396942

19.

RH5.1-CyRPA-Ripr antigen combination vaccine shows little improvement over RH5.1 in a preclinical setting.

Healer, Julie; Thompson, Jennifer K; Mackwell, Karen L; Browne, Cecille D; Seager, Benjamin A; Ngo, Anna; Lowes, Kym N; Silk, Sarah E; Pulido, David; King, Lloyd D W; Christen, Jayne M; Noe, Amy R; Kotraiah, Vinayaka; Masendycz, Paul J; Rajagopalan, Rajkannan; Lucas, Leanne; Stanford, Marianne M; Soisson, Lorraine; Diggs, Carter; Miller, Robin; Youll, Susan; Wycherley, Kaye; Draper, Simon J; Cowman, Alan F.

Front Cell Infect Microbiol ; 12: 1049065, 2022.

Artigo em Inglês | MEDLINE | ID: mdl-36605129

20.

Plasmodium vivax malaria serological exposure markers: Assessing the degree and implications of cross-reactivity with P. knowlesi.

Longley, Rhea J; Grigg, Matthew J; Schoffer, Kael; Obadia, Thomas; Hyslop, Stephanie; Piera, Kim A; Nekkab, Narimane; Mazhari, Ramin; Takashima, Eizo; Tsuboi, Takafumi; Harbers, Matthias; Tetteh, Kevin; Drakeley, Chris; Chitnis, Chetan E; Healer, Julie; Tham, Wai-Hong; Sattabongkot, Jetsumon; White, Michael T; Cooper, Daniel J; Rajahram, Giri S; Barber, Bridget E; William, Timothy; Anstey, Nicholas M; Mueller, Ivo.

Cell Rep Med ; 3(6): 100662, 2022 06 21.

Artigo em Inglês | MEDLINE | ID: mdl-35732155

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